Nimesulide Aggravates Kainic Acid-Induced Seizures in the Rat
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چکیده
منابع مشابه
Effect of seizures induced by intra-amygdaloid kainic acid on kainic acid binding sites in rat hippocampus and amygdala.
[3H]Kainic acid binding sites with a slow dissociation rate in the rat limbic system were investigated in detail. Extensively washed membranes prepared from the hippocampal formation and from the region comprising the amygdala and the piriform cortex yielded non-linear Scatchard plots. Microdissection showed that the high-affinity component (affinity constant around 1 nM) was present in the hip...
متن کاملEpileptic focus stimulation and seizure control in the rat model of kainic acid-induced limbic seizures.
The inhibitory effects of deep brain stimulation (DBS) were investigated in a rat model of kainic acid (KA)-induced limbic status epilepticus. Wistar rats were injected with 1.0 microg KA into the left amygdala after stereotactic implantation of a guide cannula and electrodes. Bipolar rectangular pulses of 0.1 msec duration and 0.1-0.3 mA amplitude were applied intermittently to the left amygda...
متن کاملKainic Acid-induced Seizures: Inflammation and Excitotoxic Neuronal Damage in the Developing Rat Hippocampus
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متن کاملDecursin attenuates kainic acid-induced seizures in mice.
Epilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells. This study served to investigate the effects of decursin on a kainic a...
متن کاملBupropion attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
Excessive release of glutamate is believed to be a major component of cell damage following excitotoxicity associated with epilepsy. Bupropion, an atypical antidepressant, has been shown to inhibit glutamate release from rat cerebrocortical nerve terminals. The present study was undertaken to investigate whether bupropion has anti-seizure and anti-excitotoxic effects by using a kainic acid (KA)...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 2008
ISSN: 0901-9928
DOI: 10.1111/j.1600-0773.2001.880509.x